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PRESS RELEASE

Media Contact:

Ariella Levine
646-943-7430
alevine@ccfa.org

DIET, NUTRITION & INFLAMMATORY BOWEL DISEASES

Interactive Webcast/Teleconference Featuring Expert Physician and Dietician Explains Connection

New York, NY—February 24, 2009—Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel diseases (IBD) are often associated with poor digestion and malabsorption of dietary protein, fat, carbohydrates, water and a wide variety of vitamins and minerals. On Tuesday, March 10, at 2 pm EST, people living with IBD can tune into a Crohn's & Colitis Foundation interactive educational webcast/teleconference entitled, "Diet, Nutrition & Inflammatory Bowel Diseases: Understanding the Connection." Sponsored by Shire plc, participants will receive insight into the often controversial topic of diet's role in the course of their chronic disease from an expert physician and dietician.

David Rubin, MD, Associate Professor of Medicine and Co-Director of the Inflammatory Bowel Disease Center at the University of Chicago Medical Center, and Tracie R. Dalessandro, MS, RD, CDN, will address:

• Why nutrition is important, including reasons for malnutrition and principles of good nutrition
• How IBD interferes with digestion, including various nutritional deficiencies
• Dietary planning methods
• Dietary management of IBD, including daily strategies to control symptoms and vitamin and mineral supplementation

"It is important for Crohn's disease and ulcerative colitis patients to understand the connection between diet, nutrition, and inflammatory bowel disease," says Dr. Rubin. "The upcoming live CCFA Nutrition event will help enable IBD patients to see how nutrition and diet plays a role in their digestion so they can better manage their disease."

Registration is available at no cost to participants via an online portal at www.ccfa.org/webcasts/nutrition and by phone at 877-547-5641 ext. 310.

About Crohn's Disease & Ulcerative Colitis


Crohn's disease and ulcerative colitis are painful, medically incurable illnesses that attack the digestive system. Crohn's disease may attack anywhere from the mouth to the anus, while ulcerative colitis inflames only the large intestine (colon). Symptoms may include abdominal pain, persistent diarrhea, rectal bleeding, fever and weight loss. Many patients require hospitalization and surgery.  These illnesses can cause severe complications, including colon cancer in patients with long-term disease. Some 1.4 million American adults and children suffer from Crohn's disease or ulcerative colitis, with as many as 150,000 under the age of 18.  Most people develop the diseases between the ages of 15 and 35.

About the Crohn's & Colitis Foundation


The Crohn's & Colitis Foundation of America's mission is to cure Crohn's disease and ulcerative colitis, and to improve the quality of life of children and adults affected by these diseases. The Foundation ranks third among leading health non-profits in the percentage of expense devoted to research toward a cure, with more than 81 cents of every dollar the Foundation spends goes to mission-critical programs. The Foundation consistently meets the standards of organizations that monitor charities, including the Better Business Bureau's Wise Giving Alliance (give.org) and the American Institute of Philanthropy (charitywatch.org). For more information, contact the Foundation at 800-932-2423 or visit www.ccfa.org.

About Shire


Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

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